You really don’t give enough information to answer your question. What bow would you put it on? … and I’m not 100% sure what you mean by a ‘regular cable guide’.
The safest answer would be, NO.
The standard cable rod diameter is 3/8″, but there is no standard shape for the rod. Some are straight, some have a double bend. Even the mounting position isn’t standard, some are above the berger hole and some are below, while some are at the bottom of the grip. Even how the cable rod attaches varies, some have a slot in the riser, some bolt to the side of the riser, some bolt to the rear of the riser. It all depends where the centroid of torques is and how the attachment is designed.
The standard cable rod has a cable slide. As the bow is drawn the slide moves away from the riser. The Chill’s reverse assist rollers don’t move. For a bow that is designed for the cable slide to move as the limbs bend, a stationary position would affect the peak DW; if the roller position is shorter than the slide’s full draw position, then the peak DW would increase, longer and the peak DW would decrease.